ALS Compendium

Title: Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin

Year Published: 2014

Observation: L75p-ApoA-I suppresses ANG expression in growth and adverse conditions and abolishes stress induced upregulation of ANG. Apopotosis was significantly increased in cells expressing L75PApoA-I. rRNA transcription is deregulated in cells expressing APOA1

Comment: ApoA-I induces cell death through attenuating anti-stress activity of ANG. ANG is associated with ALS

Citation: Del Giudice, R., Monti, D. M., Sarcinelli, C., Arciello, a, Piccoli, R., & Hu, G.-F. (2014). Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin. Cell Death & Disease, 5, e1097. doi:10.1038/cddis.2014.45

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