ALS Compendium

Title: The mouse C9ORF72 ortholog degenerate in ALS and FTD

Year Published: 2013

Observation: 311004302Rik (mouse ortholog of human C9ORF72) is most abundant in cells that are known to degenerate in ALS and was undetectable in microglia and astrocytes

Comment: Hypothesise that neuronal types most sensitive to ALS transcribe the highest level of C9ORF72

Citation: Suzuki, N., Maroof, A. M., Merkle, F. T., Koszka, K., Intoh, A., Armstrong, I., … Eggan, K. (2013). The mouse C9ORF72 ortholog degenerate in ALS and FTD. Nature Publishing Group, 16(12), 1725–1727. doi:10.1038/nn.3566

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