ALS Compendium

Title: Functional and pathological TDP-43 aggregation

Year Published: 2013

Observation: TDP43 c terminus targets TDP43 to stress granules in response to oxidative stress. TDP43 positive SGs don't cause ROS induced cell death. ROS induces toxic 130 kDa TDP43 oligomers, which regulate oxidative stress

Comment: 17-AAG reduced the number of pathological TDP-43 aggregates

Citation: Chang, H., Hou, S., Way, T., Wong, C., & Wang, I. (2013). functional and pathological TDP-43 aggregation. Nature Communications, 4, 1–11. doi:10.1038/ncomms3757

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