ALS Compendium

Title: Therapeutic modulation of eIF2 α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Year Published: 2013

Observation: TDP43 accumulation in yeast colocalizes with PUB1. TDP43 expression in fly brain induces chronic eIF2alpha phosphorylation. PABP modulates TDP43 toxicity in drosophila and PABC1 is mislocalized in human ALS spinal cord MN

Comment: Propose that compounds mitigating eIF2alpha phosphorylation could be developed as therapeutics for ALS

Citation: Kim, H., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., … Bonini, N. M. (2013). Therapeutic modulation of eIF2 α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Publishing Group, 46(2), 152–160. doi:10.1038/ng.2853

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