ALS Compendium

Title: Postnatal muscle modification by myogenicfactors modulates neuropathology and survival in an ALS mouse model

Year Published: 2013

Observation: MyoD gene transfer accelerates disease progression. Miogenic gene transfer improves rotaroad performance. PGC-1alpha doesn't improve survival or motor performance

Comment: Expression of myogenic and metabolic regulators impacts disease progression

Citation: Park, K. H. J., Franciosi, S., & Leavitt, B. R. (2013). Postnatal muscle modification by myogenicfactors modulates neuropathology and survival in an ALS mouse model. Nature Communications, 4, 1–12. doi:10.1038/ncomms3906

Back to Homepage