ALS Compendium

Title: Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Year Published: 2013

Observation: NG2+ cells in SOD1 mice display abnormal behavior in ventral gray matter before manifestation of disease. Pathological alterations to oligodendrocytes are widespread by the time mice begin to show symptoms. Mutant SOD1 deletion from oligodendroglia reduced disease

Comment: Removal of mutant SOD1 from oligodendroglia delayed disease onset and prolonged survival in ALS mice

Citation: Kang, S. H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D. W., Ostrow, L. W., … Bergles, D. E. (2013). Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nature Publishing Group, 16(5), 571–579. doi:10.1038/nn.3357

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