ALS Compendium

Title: Ligand binding and aggregation of pathogenic SOD1

Year Published: 2013

Observation: Structural perturbation of A4V SOD1 monomer, which readily aggregates. High isoproterenol concentrations may promote SOD1 oligonerization

Comment: Intervention to stabilize SOD1 dimer and inhibit aggregation is regarded as potential therapeutic strategy

Citation: Wright, G. S. A., Antonyuk, S. V, Kershaw, N. M., Strange, R. W., & Hasnain, S. S. (2013). Ligand binding and aggregation of pathogenic SOD1. Nature Communications, 4, 1710–1758. doi:10.1038/ncomms2750

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