ALS Compendium

Title: T2-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS

Year Published: 2014

Observation: Significant decrease in MTR signaling intensity in nuclei V, VII and XII and ADC in nuclei V and VII in SOD1 G93A rats. Significant increase in Iba1 (microglia) staining

Comment: Significant reduction of aparent diffusion coefficient and magnetization transfer ratio in SOD1 G93A rats

Citation: Evans, M. C., Serres, S., Khrapitchev, A. a, Stolp, H. B., Anthony, D. C., Talbot, K., … Sibson, N. R. (2014). T2-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, (July 2013), 1–9. doi:10.1038/jcbfm.2014.19

Back to Homepage