ALS Compendium

Title: The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model. Laboratory Investigation

Year Published: 2013

Observation: Modest impact of Nrf2 gene KO on disease progression in SOD1 mice. Found more proliferating astrocytes in SOD1/Nrf2 -/- than SOD1/Nrf2 +/+. Nrf2 mediated neuroprotection is not key protecive mechanism against neurodegeneration

Comment: Nrf2 is not the sole mediator for induction against antioxidant genes in SOD1 mice

Citation: Guo, Y., Zhang, Y., Wen, D., Duan, W., An, T., Shi, P., … Li, C. (2013). The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model. Laboratory Investigation, 93(7), 825–833. doi:10.1038/labinvest.2013.73

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