ALS Compendium

Title: Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

Year Published: 2013

Observation: Ex vivo delivery of GDNF and VEGF but not IGF-1 or BDNF prolongs survival of ALS rats. Combined delivery of GDNF and VEGF extends survival in SOD1 rats

Comment: Ex vivo delivery of GDNF and VEGF extended survival and protected neuromuscular junctions and motor neurons

Citation: Krakora, D., Mulcrone, P., Meyer, M., Lewis, C., Bernau, K., Gowing, G., … Suzuki, M. (2013). Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model, 21(8), 1602–1610. doi:10.1038/mt.2013.108

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