ALS Compendium

Title: Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis

Year Published: 2013

Observation: NSC34 SOD1 G93A cells overexpressing PRDX3 or NRF2 showed a decrease in endogenous oxidation stress levels by 40 and 50% and cell survival by 30%. No significant effects in survival in vivo

Comment: Overexpressing PRDX3 or NRF2 in vitro increases survival by 30%

Citation: Nanou, A., Higginbottom, A., Valori, C. F., Wyles, M., Ning, K., Shaw, P., & Azzouz, M. (2013). Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis, 21(8), 1486–1496. doi:10.1038/mt.2013.115

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