ALS Compendium

Title: FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/ FTLD

Year Published: 2013

Observation: FUS regulates gene expression in otor neurons, cortical neurons and glial cells. FUS mediated alternative splicing profiles are similar in cortical and motor neurons. Glial cells are similar to motor and cortical neurons in FUS regulated gene expression profiles

Comment: FUS regulated transcriptome profiles in each cell type may determine cellular fate in association with FUS mediated ALS

Citation: Fujioka, Y., Ishigaki, S., Masuda, A., Iguchi, Y., Udagawa, T., Watanabe, H., … Sobue, G. (2013). FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/ FTLD. doi:10.1038/srep02388

Back to Homepage