ALS Compendium

Title: Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

Year Published: 2013

Observation: FUS is important for homologous recombination and NHES mediated DSB repair. FUS is important for induction of DDR response to DNA damage. Recruitment of FUS to sites of DNA damage apprears to reach max. levels while gammaH2AX is still accumulating. FUS and HDAC1 form a complex in response to DNA damage

Comment: fALS FUS mutants are defective in DDR and DNA repair

Citation: Wang, W., Pan, L., Su, S. C., Quinn, E. J., Sasaki, M., Jimenez, J. C., … Tsai, L. (2013). Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nature Publishing Group, 16(10), 1383–1391. doi:10.1038/nn.3514

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