ALS Compendium

Title: Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations

Year Published: 2013

Observation: Created a simulation that effectively predicts that conformational change of His114 results in loss of ribonucleolytic activity and that reduction of solvent accessible surface area of nuclear localization signal residues RRR results in loss of nuclear translocation activity.

Comment: Method might be able to infer a new ANG mutation ahead of experimental results

Citation: Padhi, A. K., Jayaram, B., & Gomes, J. (2013). Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations. Scientific Reports, 3, 1225. doi:10.1038/srep01225

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