ALS Compendium

Title: Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration. Cell Death and Differentiation

Year Published: 2013

Observation: found that motoneurons were selectively vulnerable to acidotoxicity in vitro, and that acidotoxicity was partially reduced in asic1a-deficient motoneuron cultures. Cross-breeding of SOD1(G93A) ALS mice with asic1a-deficient mice delayed the onset and progression of motor dysfunction in SOD1 mice. Found a strong increase in ASIC2 expression in motoneurons of SOD1 mice and sporadic ALS patients during disease progression.

Comment: evidence for the involvement of acidotoxicity and ASIC channels in motoneuron degeneration

Citation: Behan, a T., Breen, B., Hogg, M., Woods, I., Coughlan, K., Mitchem, M., & Prehn, J. H. M. (2013). Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration. Cell Death and Differentiation, 20(4), 589–98. doi:10.1038/cdd.2012.158

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