ALS Compendium

Title: Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

Year Published: 2013

Observation: C9RANT immunoreactive inclusions are present in neurons but not astrocytes. C9RANT immunoreactivity was detected in both cytoplasmic and nuclear inclusions in sertoli cells but not in germ cells of tubules

Comment: Anti-C9RANT Immunoreactivity Is Specific to c9FTD/ALS

Citation: Ash, P. E. a, Bieniek, K. F., Gendron, T. F., Caulfield, T., Lin, W.-L., Dejesus-Hernandez, M., … Petrucelli, L. (2013). Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron, 77(4), 639–46. doi:10.1016/j.neuron.2013.02.004

Back to Homepage