ALS Compendium

Title: Adeno-associated Virus – mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis

Year Published: 2014

Observation: Nuclear SOD1 plays a role against genomic DNA damage by endogeneous and environmental regulation of ROS. ROS stimulates SOD1 phosphorylation in a Mec1/Dun1 dependent manner. SOD1 regulates gene expression in response to elevated ROS

Comment: SOD1 is a nuclear transcription factor that regulates the expression of oxidative stress and repair genes

Citation: Patel, P., Kriz, J., Gravel, M., Soucy, G., Bareil, C., Gravel, C., & Julien, J. (2014). Adeno-associated Virus – mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis, 22(3), 498–510. doi:10.1038/mt.2013.239

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