ALS Compendium

Title: C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

Year Published: 2012

Observation: GGGGCC repeats form RNA G-quadrupexes. GGGGCC G-quadruplexes are highly stable, and their stability is cation dependent

Comment: C9orf72 hexanucleotide expansion can form a stable G-quadruplex

Citation: Fratta, P., Mizielinska, S., Nicoll, A. J., Zloh, M., Fisher, E. M. C., Parkinson, G., & Isaacs, A. M. (2012). C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes. Scientific Reports, 2, 1016. doi:10.1038/srep01016

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