ALS Compendium

Title: A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Year Published: 2012

Observation: activation of calpain, a Ca2+-dependent cysteine protease, by upregulation of Ca2+-permeable AMPA receptors generates c terminal cleaved TDP-43 fragments and causes mislocalization of TDP-43 in the MN expressing glu/arg site-unedited GluA2 of conditional ADAR2 knockout mice that mimic the ALS pathology

Comment: TDP-43 is highly vulnerable to Calpain

Citation: Yamashita, T., Hideyama, T., Hachiga, K., Teramoto, S., Takano, J., Iwata, N., … Kwak, S. (2012). A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nature Communications, 3, 1307. doi:10.1038/ncomms2303

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