ALS Compendium

Title: Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons

Year Published: 2012

Observation: Found 11 ANG-ALS variants. ANG-ALS variants affect structure of catalyitic site and either increase or decrease RNase activity and lack the avility to form stress granules

Comment: ANG-ALS variants lack the ability to form stress granules

Citation: Thiyagarajan, N., Ferguson, R., Subramanian, V., & Acharya, K. R. (2012). Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons. Nature Communications, 3, 1121. doi:10.1038/ncomms2126

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