ALS Compendium

Title: Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions

Year Published: 2012

Observation: KO FUS and found that FUS is likely to exert neuron-specific gene regulation by modulating alternative splicing events. FUS is bound to the antisense RNA strand at the promoter regions, which downregulated transcription of the coding strand

Comment: FUS regulates alternative splicing events and transcriptions in a position-dependent manner

Citation: Ishigaki, S., Masuda, A., Fujioka, Y., Iguchi, Y., Katsuno, M., Shibata, A., … Ohno, K. (2012). Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Scientific Reports, 2, 529. doi:10.1038/srep00529

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