ALS Compendium

Title: Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Year Published: 2012

Observation: RNA is altered after in vivo FUS/TLS depletion. FUS and TDP43 intersect in processing long pre mRNAs. Long pre mRNAs are altered in ALS MNs

Comment: Suggest common loss-of-function pathway as one component underlying motor neuron death from misregulation of TDP-43 or FUS/TLS.

Citation: Lagier-Tourenne, C., Polymenidou, M., Hutt, K. R., Vu, A. Q., Baughn, M., Huelga, S. C., … Yeo, G. W. (2012). Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nature Neuroscience, 15(11), 1488–97. doi:10.1038/nn.3230

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