ALS Compendium

Title: Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. Journal of Cerebral Blood Flow and Metabolism

Year Published: 2012

Observation: Found an SBF decrease in ALS mice, decreased capillary diameter, density and RBC velocity. Found flow metabolism uncoupling in spinal cord

Comment: suggests that early and progressive flow metabolism uncoupling could profoundly involve in the whole disease process as a vascular factor of ALS pathology

Citation: Miyazaki, K., Masamoto, K., Morimoto, N., Kurata, T., Mimoto, T., Obata, T., … Abe, K. (2012). Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 32(3), 456–67. doi:10.1038/jcbfm.2011.155

Back to Homepage