ALS Compendium

Title: Species-dependent neuropathology in transgenic SOD1 pigs

Year Published: 2014

Observation: Found accumulation of hSOD1 in motor neurons in the ventral horn of lumbar spinal cord. Decrease in ChAT positive large motor neurons in 8 month old pigs. Found hSOD1 nuclear inclusions

Comment: SOD1-PCBP1 interaction is probably responsible for nuclear SOD1 accumulation

Citation: Yang, H., Wang, G., Sun, H., Shu, R., Liu, T., Wang, C.-E., … Lai, L. (2014). Species-dependent neuropathology in transgenic SOD1 pigs. Cell Research, 1–18. doi:10.1038/cr.2014.25

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