ALS Compendium

Title: Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain

Year Published: 2012

Observation: FUS binds along the whole lenght of nascent RNA soon after its transcription. FUS binds to long RNA regions around the expressed exons. FUS and TDP43 regulate genes involved in neuronal development

Comment: found that both FUS and TDP43 regulate genes that function in neuronal development.

Citation: Rogelj, B., Easton, L. E., Bogu, G. K., Stanton, L. W., Rot, G., Curk, T., … Ule, J. (2012). Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. Scientific Reports, 2, 603. doi:10.1038/srep00603

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