ALS Compendium

Title: The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

Year Published: 2012

Observation: Downregulation of GPNMB increased motor neuron vulnerability. Fragments of GPNMB in spinal cord attenuated the neurotoxicity of SOD1 G93A mice

Comment: GPNMB can be a target for therapeutic intervention in ALS

Citation: Tanaka, H., Shimazawa, M., Kimura, M., Takata, M., Tsuruma, K., Yamada, M., … Hara, H. (2012). The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis. Scientific Reports, 2, 573. doi:10.1038/srep00573

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