ALS Compendium

Title: EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

Year Published: 2012

Observation: A 50% decrease in Epha4 expressio significantly increased motor performance and survival (by 57%) in SOSD1 mice. Epha4 attenuates disease progression in ALS patients induced by mutant TDP43 overexpression and SMN1 KO

Comment: Epha4 generically modulates the vulnerability of MNs to axonal degeneration

Citation: Van Hoecke, A., Schoonaert, L., Lemmens, R., Timmers, M., Staats, K. a, Laird, A. S., … Robberecht, W. (2012). EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nature Medicine, 18(9), 1418–22. doi:10.1038/nm.2901

Back to Homepage