ALS Compendium

Title: Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

Year Published: 2012

Observation: VCP heterozygous knock in mice develop slowly progressing muscle weakness. Found age-dependent motor neurodegeneration, TDP43 pathology and mitochondrial aggregation

Comment: Knock-in VCP mice shows ALS characteristics

Citation: Yin, H. Z., Nalbandian, a, Hsu, C.-I., Li, S., Llewellyn, K. J., Mozaffar, T., … Weiss, J. H. (2012). Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice. Cell Death & Disease, 3, e374. doi:10.1038/cddis.2012.115

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