ALS Compendium

Title: IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1

Year Published: 2011

Observation: LT-betaR activation is sufficient to cause LIGHT dependent death of MNs. IFNgamma induces MN death in a LIGHT dependent manner. LIGHT triggers a caspase-dependent signaling pathway in MNs. ALS mutant astrocytes selectively kill MNs through the IFNgamma/LT-betaR pathway

Comment: propose that IFNγ contributes to a cross-talk between motoneurons and astrocytes causing the selective loss of some motoneurons following activation of the LIGHT-induced death pathway.

Citation: Aebischer, J., Cassina, P., Otsmane, B., Moumen, a, Seilhean, D., Meininger, V., … Raoul, C. (2011). IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1. Cell Death and Differentiation, 18(5), 754–68. doi:10.1038/cdd.2010.143

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