ALS Compendium

Title: Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

Year Published: 2014

Observation: Found that neither SOD1 or TDP43 contribute to sALS astrocyte toxicity. Found that MN death triggered by sALS/fALS astrocytes is Bax dependent but caspase independent.

Comment: Death of motor neurons triggered by sALS and fALS astrocytes occurs through necroptosis

Citation: Re, D. B., Le Verche, V., Yu, C., Amoroso, M. W., Politi, K. a, Phani, S., … Przedborski, S. (2014). Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS. Neuron, 81(5), 1001–8. doi:10.1016/j.neuron.2014.01.011

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