ALS Compendium

Title: CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit

Year Published: 2011

Observation: Intraspinal injection leads to a highly CNS specific expression of G-CSF. BMS decrease was delayed by >2 weeks, onset of paralisis was delayed and survival was increased by 7%

Comment: intraspinal delivery improves efficacy of G-CSF treatment in SOD1 mice

Citation: Henriques, A., Pitzer, C., Dittgen, T., Klugmann, M., Dupuis, L., & Schneider, A. (2011). CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit. Molecular Therapy : The Journal of the American Society of Gene Therapy, 19(2), 284–92. doi:10.1038/mt.2010.271

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