ALS Compendium

Title: Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

Year Published: 2010

Observation: An aberrrantly modified form of wtSOD1 present in sALS inhibits conventional kinesion-based FAT through a mechanism involving p38 activation

Comment: Wild type SOD1 can be pathogenic in sALS

Citation: Bosco, D. a, Morfini, G., Karabacak, N. M., Song, Y., Gros-Louis, F., Pasinelli, P., … Brown, R. H. (2010). Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nature Neuroscience, 13(11), 1396–403. doi:10.1038/nn.2660

Back to Homepage