ALS Compendium

Title: Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration.

Year Published: 2014

Observation: MMP-9 is selectively expressed in fast alpha-motor neurons. MMP-9 is required for muscular denervation and enhances activation of ER stress. MMP-9 is sufficient to induce degeneration in fast alpha-motor neurons

Comment: Reduction of MMP-9 significantly delayed muscle denervation

Citation: Kaplan, A., Spiller, K. J., Towne, C., Kanning, K. C., Choe, G. T., Geber, A., … Henderson, C. E. (2014). Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration. Neuron, 81(2), 333–48. doi:10.1016/j.neuron.2013.12.009

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