ALS Compendium

Title: Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

Year Published: 2009

Observation: SOD1 mice transplanted with VEGF human neural stem cells showed a significant delay on motor performance decline and prolonged lifespan

Comment: intrathecal transplantation of human NSCs genetically modified to overexpress neurotrophic factor(s) might be of value in the treatment of ALS patients

Citation: Hwang, D. H., Lee, H. J., Park, I. H., Seok, J. I., Kim, B. G., Joo, I. S., & Kim, S. U. (2009). Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Therapy, 16(10), 1234–44. doi:10.1038/gt.2009.80

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