ALS Compendium

Title: A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

Year Published: 2009

Observation: Comparable ER stress preceding pathology in VUL and RES motoneurons. VUL MNs are selectively prone to ER stress. Reducing ER stress aleviated disease manifestations

Comment: ER stress responses in specific motoneuron subtypes influence the progressive manifestations of weakening and paralysis

Citation: Saxena, S., Cabuy, E., & Caroni, P. (2009). A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nature Neuroscience, 12(5), 627–36. doi:10.1038/nn.2297

Back to Homepage