ALS Compendium

Title: Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig’s disease in rats via TDP-43 overexpression

Year Published: 2009

Observation: TDP43 gene transfer caused gliosis for microglia and astrocytes. Found apoptotic nuclei and loss of neurons in the SN

Comment: TDP43 gene transfer mimicks ALS and FTD pathology

Citation: Tatom, J. B., Wang, D. B., Dayton, R. D., Skalli, O., Hutton, M. L., Dickson, D. W., & Klein, R. L. (2009). Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig’s disease in rats via TDP-43 overexpression. Molecular Therapy : The Journal of the American Society of Gene Therapy, 17(4), 607–13. doi:10.1038/mt.2009.3

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