ALS Compendium

Title: Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis

Year Published: 2009

Observation: Intracellular Abeta causes H4 cell apoptotic cell death. SOD1 directly interacts with Abeta. Abeta decreases the enxymatic activity of SOD1

Comment: potential role for Abeta in the development of ALS by interacting with SOD1

Citation: Yoon, E. J., Park, H. J., Kim, G. Y., Cho, H. M., Choi, J. H., Park, H. Y., … Kang, S. M. (2009). Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis. Experimental & Molecular Medicine, 41(9), 611–7. doi:10.3858/emm.2009.41.9.067

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